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Top 10 Reasons for Infertility in Men and Women: Understanding the Causes

Brenda Albano

September 16, 2026

Graphic titled Top 10 Reasons for Infertility in Men and Women showing a concerned couple sitting together holding a test.

Top 10 Reasons for Infertility: Understanding the Root Causes

Trying to have a baby when it’s not happening can feel incredibly lonely, even when you’re surrounded by love. Month after month, the waiting, the hoping, the wondering, it can be heartbreaking.

If you’re going through this, or someone close to you is, please know: your feelings are valid. Infertility can be an emotional and uncertain journey, and whatever you’re feeling along the way is okay.

Fertility struggles touch more people than most of us realize. And while it can feel like an overwhelming mystery, understanding the reasons for infertility, both in women and men, can be an empowering first step.

Infertility can have many possible causes, and there isn’t always an immediate explanation. Understanding these factors can help you ask the right questions and work with your healthcare provider to determine the next steps.

What Is Infertility?

Infertility isn’t just a medical term, it’s the quiet questions, the long waits, and the emotional weight that often come with it. It’s usually defined as not getting pregnant after a year of trying, or six months if you’re over 35.

But that doesn’t tell the whole story. Infertility may be linked to irregular periods, changes in sperm health, or factors that don’t cause any obvious signs at all.

It’s not about blame, and it doesn’t necessarily mean there’s no path forward. Understanding the possible causes can help you have more informed conversations with your healthcare provider and determine what steps may be appropriate for you.

What Are Some Common Female Infertility Causes?

When a woman has difficulty getting pregnant, the reason isn’t always obvious at first. Fertility can be influenced by several factors, from hormonal changes and ovulation to reproductive health and age. Here are some of the causes doctors and researchers see most often:

1. Ovulation Disorders

One of the biggest reasons for infertility in women is trouble with ovulation.

If you’re not releasing eggs regularly, or at all, it’s going to be tough to conceive. Conditions like polycystic ovary syndrome (PCOS) or other hormone imbalances can mess with your cycle.

According to a study published in Clinical Medicine Insights: Reproductive Health, PCOS is one of the leading causes of anovulation and accounts for up to 70% of infertility in women with irregular ovulation.

2. Age

We hear about this a lot because age does play a role in fertility. As women get older, the number and quality of their eggs naturally decline. This can make it more difficult to conceive and can increase the risk of pregnancy complications.

3. Blocked or Damaged Fallopian Tubes

Even if you’re ovulating perfectly, fallopian tube blockages can keep sperm from meeting the egg. This might happen after pelvic infections, past surgeries, or conditions like pelvic inflammatory disease (PID).

4. Endometriosis

Endometriosis isn’t just painful periods, it can also interfere with fertility. This condition causes tissue similar to the uterine lining to grow outside the uterus, sometimes leading to scarring or blockages that mess with both ovulation and implantation.

5. Uterine or Cervical Abnormalities

Abnormalities like fibroids, polyps, or structural differences such as a septate uterus can affect fertility, implantation, or pregnancy. Some are present at birth, while others develop over time.

What About Male Infertility Causes?

Yes, fertility struggles are just as likely to involve male issues as female ones. In fact, about 30 to 40% of infertility cases involve male factors, according to the American Urological Association.

6. Sperm Disorders

Low sperm count, poor movement (motility), or abnormal shape (morphology) are among the top male infertility causes. Even when sperm are present, they need to be healthy enough to move through the reproductive tract and fertilize the egg. Erectile dysfunction can also make conception more difficult by affecting the ability to have intercourse.

7. Age (Yes, It Affects Men Too)

While men don’t have a sharp fertility drop like women do, sperm quality does decline with age, especially after 40. Studies from the JBRA Assisted Reproduction suggest that older men are more likely to experience reduced sperm motility and DNA fragmentation.

8. Hormonal Imbalances

Testosterone and other hormones play a key role in sperm production. When hormone levels are disrupted by conditions affecting the reproductive system, certain medications, or other health factors, sperm production and fertility may be affected.

9. Genetic Conditions

Certain genetic conditions can affect sperm production, including Klinefelter syndrome and microdeletions of the Y chromosome. Depending on the condition, they may lead to very low or absent sperm production and contribute to infertility.

Are There Lifestyle or Environmental Infertility Causes?

Sometimes the issue is less about anatomy and more about habits or the environment you’re in every day.

10. Lifestyle, Environment, and Health Conditions

Both men and women can face fertility challenges due to:

  • Being underweight or having obesity
  • A diet lacking important nutrients
  • Chronic stress
  • Exposure to certain environmental chemicals
  • Smoking, excessive alcohol use, and recreational drugs
  • Chronic health conditions
  • Certain medications

What Are the Signs You Can’t Get Pregnant?

Infertility does not always cause noticeable symptoms. However, certain changes or health factors may signal that it’s worth talking with a healthcare provider about your fertility:

  • Irregular or missed periods
  • Painful periods or ongoing pelvic pain
  • Irregular or absent ovulation
  • Low libido
  • A history of pelvic infections or reproductive surgery
  • A history of recurrent miscarriages
  • Known hormone-related conditions, such as PCOS or thyroid disorders
  • Trying to conceive without success for 12 months, or 6 months if you’re over 35

Natural and Lifestyle Ways to Support Fertility

If you’re feeling overwhelmed by all the possible infertility causes, there are simple lifestyle habits that may help support your overall reproductive health.

1. Focus on Nourishing Foods

What you eat plays a big role in overall health, including hormonal balance, ovulation, and sperm health.

Think whole foods, such as leafy greens, colorful vegetables, healthy fats like avocado and olive oil, nuts, seeds, and good sources of protein. Limiting highly processed foods, added sugars, and excess caffeine can also be part of a balanced approach to fertility.

2. Stay Active, but Don’t Overdo It

Regular, moderate exercise can support overall health and healthy hormone function. But too much high-intensity exercise, especially when combined with inadequate nutrition, may disrupt ovulation in some women. It’s about finding a balance that keeps your body active without leaving you depleted.

3. Reduce Stress Where You Can

Stress alone may not be the root cause of infertility, but chronic stress can affect overall health and may influence reproductive function. Try carving out even a few minutes a day to breathe deeply, journal, take a walk, or do something that helps you relax.

4. Limit Exposure to Toxins

Some chemicals found in everyday products may affect reproductive health, so reducing unnecessary exposure can be a practical step. Using glass or stainless-steel containers when practical, following product safety instructions, and choosing fragrance-free personal care products are simple ways to be mindful of what you’re exposed to each day.

5. Support Your Body with Natural Supplements

Along with healthy lifestyle habits, some people choose natural supplements to complement their approach to fertility. Herbs, vitamins, and other nutrients may provide nutritional support while you work with your healthcare provider to understand your individual needs.

Whole Family Products has several formulas designed with fertility and reproductive wellness in mind. Fertile Balance Cream provides topical progesterone support for women, while Fertile Male is formulated with nutrients and herbs traditionally used to support male reproductive health. DIM 150 provides concentrated DIM, commonly used to support healthy estrogen metabolism and hormone balance. Organic Ashwagandha contains an adaptogenic herb traditionally used to support the body during periods of stress and promote stamina.

Fertile Balance progesterone cream infographic highlighting fertility support, hormone balance, and reproductive wellness.

If you’re considering adding supplements to your routine, especially while taking medications or undergoing fertility treatment, talk with your healthcare provider first.

Final Thoughts

Understanding the possible causes of infertility can help you make more informed choices about your health and know what questions to bring to your healthcare provider. From nutrition and physical activity to stress management and limiting environmental exposures, small, consistent changes can be part of a healthy approach to reproductive wellness.

If you’re taking medications, undergoing fertility treatment, or have an underlying health condition, talk with your healthcare provider before adding any new supplement.

Infertility can have many possible causes, and finding the right answers may take time. Focus on the factors you can address, ask questions, and work with a qualified healthcare provider to determine what makes sense for you.

Whole Family Products provides helpful fertility tips and articles to complement healthy lifestyle habits and reproductive wellness goals. Visit our blog for more helpful information.

DISCLAIMER: These statements have not been approved by the FDA and we do not make any claims that this product or ingredient will cure, prevent, treat or even diagnose any disease. Studies linked here were conducted by independent labs for informational purposes. Please check with your doctor of choice for information regarding your own personal health profile and needs.

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